Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
BlackRock Institutional Trust Company, N.A. 2,734,070 11.99 11,002 6/30/19
Fidelity Management & Research Company 1,959,576 8.59 369,842 6/30/19
The Vanguard Group, Inc. 1,271,657 5.58 127,807 6/30/19
OrbiMed Advisors, LLC 909,814 3.99 -271,400 6/30/19
Redmile Group, LLC 888,705 3.90 -333,700 6/30/19
Dimensional Fund Advisors, L.P. 753,164 3.30 30,705 6/30/19
Lord, Abbett & Co. LLC 750,843 3.29 42,771 6/30/19
Victory Capital Management Inc. 722,665 3.17 -279,325 6/30/19
State Street Global Advisors (US) 595,827 2.61 54,958 6/30/19
Gilder Gagnon Howe & Co. LLC 549,700 2.41 -3,598 6/30/19

* Insider values reflect direct beneficial ownership.

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