Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
BlackRock Institutional Trust Company, N.A. 2,388,901 10.60 37,738 12/31/18
OrbiMed Advisors, LLC 1,100,000 4.88 -511,200 12/31/18
Redmile Group, LLC 1,091,395 4.84 -381,200 12/31/18
Deerfield Management Company, L.P. 1,076,402 4.77 -150,659 12/31/18
The Vanguard Group, Inc. 1,041,034 4.62 8,600 12/31/18
Wellington Management Company, LLP 853,798 3.79 -739,615 12/31/18
Victory Capital Management Inc. 787,515 3.49 766,505 12/31/18
Dimensional Fund Advisors, L.P. 727,294 3.23 44,820 12/31/18
PAR Capital Management, Inc. 702,342 3.12 -9,175 12/31/18
Flanders Scott N 662,792 2.94 46,926 3/31/19

* Insider values reflect direct beneficial ownership.

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