Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
BlackRock Institutional Trust Company, N.A. 2,006,469 10.77 77,347 12/31/17
OrbiMed Advisors, LLC 1,834,700 9.85 -- 12/31/17
Redmile Group, LLC 1,558,914 8.37 221,291 12/31/17
Cannell Capital, LLC 1,091,878 5.86 -301,988 12/31/17
Deerfield Management Company, L.P. 1,013,916 5.44 340,922 12/31/17
The Vanguard Group, Inc. 978,756 5.26 6,245 12/31/17
Wellington Management Company, LLP 971,396 5.22 -160,827 12/31/17
Renaissance Technologies LLC 909,600 4.88 31,300 12/31/17
Dimensional Fund Advisors, L.P. 644,641 3.46 -9,052 12/31/17
Concept Asset Management 556,550 2.99 -21,900 12/31/17

* Insider values reflect direct beneficial ownership.

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