Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
BlackRock Institutional Trust Company, N.A. 1,929,122 10.41 -5,013 9/30/17
OrbiMed Advisors, LLC 1,834,700 9.90 -- 9/30/17
Cannell Capital, LLC 1,357,045 7.32 -36,821 10/19/17
Redmile Group, LLC 1,337,623 7.22 114,289 9/30/17
Wellington Management Company, LLP 1,132,223 6.11 4,918 9/30/17
The Vanguard Group, Inc. 972,511 5.25 -2,273 9/30/17
Renaissance Technologies LLC 878,300 4.74 -65,300 9/30/17
Deerfield Management Company, L.P. 672,994 3.63 -17,354 9/30/17
Dimensional Fund Advisors, L.P. 653,693 3.53 -2,765 9/30/17
Concept Asset Management 578,450 3.12 -7,500 9/30/17

* Insider values reflect direct beneficial ownership.

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