Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
BlackRock Institutional Trust Company, N.A. 2,057,172 10.83 50,703 3/31/18
OrbiMed Advisors, LLC 1,834,700 9.66 -- 3/31/18
Wellington Management Company, LLP 1,709,755 9.00 738,359 3/31/18
Redmile Group, LLC 1,330,495 7.01 -228,419 3/31/18
Cannell Capital, LLC 1,165,882 6.14 74,004 3/31/18
Deerfield Management Company, L.P. 1,030,802 5.43 16,886 3/31/18
The Vanguard Group, Inc. 978,960 5.15 204 3/31/18
PAR Capital Management, Inc. 813,856 4.29 312,998 3/31/18
Renaissance Technologies LLC 802,200 4.22 -107,400 3/31/18
Dimensional Fund Advisors, L.P. 628,249 3.31 -16,392 3/31/18

* Insider values reflect direct beneficial ownership.

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