Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
BlackRock Institutional Trust Company, N.A. 2,321,809 12.11 264,637 6/30/18
OrbiMed Advisors, LLC 1,834,700 9.57 -- 6/30/18
Wellington Management Company, LLP 1,721,159 8.98 11,404 6/30/18
Redmile Group, LLC 1,377,895 7.19 47,400 6/30/18
Deerfield Management Company, L.P. 1,104,952 5.76 74,150 6/30/18
The Vanguard Group, Inc. 1,047,280 5.46 68,320 6/30/18
Cannell Capital, LLC 1,029,854 5.37 -136,028 6/30/18
PAR Capital Management, Inc. 813,856 4.24 -- 6/30/18
Renaissance Technologies LLC 652,600 3.40 -149,600 6/30/18
Dimensional Fund Advisors, L.P. 569,800 2.97 -58,449 6/30/18

* Insider values reflect direct beneficial ownership.

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