Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
BlackRock Institutional Trust Company, N.A. 2,351,163 12.12 29,354 9/30/18
OrbiMed Advisors, LLC 1,611,200 8.30 -223,500 9/30/18
Wellington Management Company, LLP 1,593,413 8.21 -127,746 9/30/18
Redmile Group, LLC 1,472,595 7.59 94,700 9/30/18
Deerfield Management Company, L.P. 1,227,061 6.32 122,109 9/30/18
The Vanguard Group, Inc. 1,032,434 5.32 -14,846 9/30/18
PAR Capital Management, Inc. 711,517 3.67 -102,339 9/30/18
Dimensional Fund Advisors, L.P. 682,474 3.52 112,674 9/30/18
Cannell Capital, LLC 638,259 3.29 -391,595 9/30/18
Flanders Scott N 615,866 3.17 50,000 11/15/18

* Insider values reflect direct beneficial ownership.

Copyright Thomson Reuters Corporation