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Ownership

Top Holders
 Shares Held% O/SShare ChangeFiling Date
Deerfield Management Company, L.P.2,640,60914.4012/31/16
BlackRock Institutional Trust Company, N.A.1,895,16510.3199,73112/31/16
OrbiMed Advisors, LLC1,820,0009.95,00012/31/16
Wellington Management Company, LLP1,513,9538.34,97012/31/16
Redmile Group, LLC997,6215.4997,62112/31/16
The Vanguard Group, Inc.880,1394.8-13,35712/31/16
Renaissance Technologies LLC789,5004.335,80012/31/16
Cannell Capital, LLC667,9473.6667,94712/31/16
Concept Asset Management607,2503.3314,45012/31/16
Hawk Ridge Capital Management LP604,1143.310,00012/31/16


Ownership data based on most recent publicly available data according to Thomson Reuters.

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