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Ownership

Top Holders
 Shares Held% O/SShare ChangeFiling Date
BlackRock Institutional Trust Company, N.A.2,029,39911.0134,23403/31/17
OrbiMed Advisors, LLC1,820,0009.9003/31/17
Cannell Capital, LLC1,762,0609.6845,69604/28/17
Deerfield Management Company, L.P.1,518,2468.2-1,122,36305/08/17
Wellington Management Company, LLP1,473,7878.0-40,16603/31/17
Redmile Group, LLC1,191,3346.5193,71303/31/17
The Vanguard Group, Inc.932,4965.152,35703/31/17
Renaissance Technologies LLC878,9004.889,40003/31/17
Dimensional Fund Advisors, L.P.645,4323.556,76703/31/17
Concept Asset Management615,8503.38,60003/31/17


Ownership data based on most recent publicly available data according to Thomson Reuters.

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