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Ownership

Top Holders
 Shares Held% O/SShare ChangeFiling Date
BlackRock Institutional Trust Company, N.A.1,934,13510.4-95,26406/30/17
OrbiMed Advisors, LLC1,834,7009.914,70006/30/17
Cannell Capital, LLC1,551,4008.4-281,50808/18/17
Redmile Group, LLC1,223,3346.632,00006/30/17
Wellington Management Company, LLP1,127,3056.1-346,48206/30/17
The Vanguard Group, Inc.974,7845.342,28806/30/17
Renaissance Technologies LLC943,6005.164,70006/30/17
Deerfield Management Company, L.P.690,3483.7-1,950,26106/30/17
Dimensional Fund Advisors, L.P.656,4583.511,02606/30/17
Concept Asset Management585,9503.2-29,90006/30/17


Ownership data based on most recent publicly available data according to Thomson Reuters.

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